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                  GAS CHROMATOGRAPHY IN TB DIAGNOSIS

I have a particular interest in cancer diagnosis so when I discovered a unique portable gas chromatography platform, the Znose, I was using in a cancer project, I realised that it may also have a role in TB diagnosis as a field-deployable point of care diagnostic system.

The Znose can identify bacteria without the need for derivitisation, so signatures can be library matched using live bacteria in a medium such as sputum, without first having to kill the bacteria being the normal procedure with other forms of gas chromatography.

The Znose, being a GC platform, unlike an electronic nose, is able to separate individual chemical components of bacteria that allow a more critical sample analysis to be made whilst having a resolving ceiling of pp billion where an electronic nose has a resolving ceiling of pp million; so the Znose has exquisite sensitivity.

When I introduced this platform to the London School of Hygiene, they were impressed, and we formed a collaboration which they continued to expand, leading to their publication in 2012.

The Znose is currently being used in the US to diagnose TB in conjunction with other platforms.

Collaboration: London School of Hygiene and Tropical Medicine

Collaborator: Dr Ruth McNerney.

Publication: Production of volatile organic compounds by mycobacteria. 2012

http://femsle.oxfordjournals.org/content/328/2/150

Authors: Ruth McNerney, Kim Mallard, Phyllis Ifeoma Okolo & Claire Turner.

37th World Conference Tuberculosis and Lung Disease - Paris 2006

www.theunion.org/what-we-do/.../2006_union_world_conference_web.pdf

Gino Francesco patent: A method of detecting and identifying bacteria
WO 2006079846 A1 2006

http://www.google.co.uk/patents/WO2006079846A1?cl=en



copyright © Gino Francesco 2013