I am an innovator in experimental medicine focusing on tumour angiogenisis and cancer diversity within tumours. I have used my experiences gained in cancer studies to create some new ideas for the purpose of feasibility studies in the treatment of tuberculosis, which have resulted in a number of collaborations with some leading TB Institutes, that has led to on-going research by them, and also produced a number of publications and patents.
Drug delivery by inhalation is an important new route in the treatment of pulmonary tuberculosis, and my Innovations rely completely on this practice. I conceived the idea that the use of a weak acid by inhalation is a method able to increase the bactericidal activity of oral pyrazinamide that can lead to TB therapy duration being reduced by a huge margin. This has resulted in the development of pyrazinoic acid salts and esters for use in trials. This concept was first disclosed at the INTERTB symposium London 2009 by my original collaborator Prof Denny Mitchison, and is now being developed by separate International collaborations.
I have been looking at methods to control bovine tuberculosis on farms, and one idea is to create badger feeding stations near badger setts, as a way in which an oral vaccine can be better administered to badgers, and can also be observed using imaging technologies. Another innovation attached to this concept, is the use of UV responsive dye that self-marks badgers as they feed so badgers who have been vaccinated can be identified from badgers who have not.
All of the ideas and concepts revealed on this site are my own original material or that of my collaborators, and are at early stage development or subject to new patent applications, but are still unproven and need to undergo proof of concept.
My collaborations to date have included: London School of Hygiene; St Georges University London; Kings College London; Open University; Surrey University.